FL496, an FL118-derived small molecule, induces growth inhibition, senescence, and apoptosis of malignant pleural mesothelioma (MPM) cells, and exhibits anti-MPM tumor efficacy strikingly superior to the pemetrexed-cisplatin combination.

pemetrexed - Generic mfg.

FL118 - Canget

cisplatin - Generic mfg.

FL-496 - Canget

http://www.ncbi.nlm.nih.gov/pubmed/41121175

Aimee Stablewski; Dan Li; Emma Zhang; Fengzhi Li; Ieman A M Aljahdali; Qingyong Li; Rami Azrak; Renyuan Zhang; Wenchao Wang; Wenjie Wu; Xiang Ling

Oct 22, 2025