Some plasma derived FVIII concentrates activated FXII leading to kallikrein and bradykinin formation in vitro, while recombinant FVIII concentrates did not

Advate (octocog alfa) - Takeda

Humate-P, Haemate-P (human plasma derived von Willebrand factor/FVIII complex) - CSL Behring

Kovaltry (octocog alfa) - Bayer, CSL Behring

Haemoctin (human plasma derived coagulation factor VIII) - ADMA Biologics

Octanate (human Factor VIII/von Willebrand Factor) - Octapharma

Beriate P (human plasma derived coagulation factor VIII) - CSL Behring

Brodde M.1,2; Oenning S.1; Kehrel B.E.1

Mar 1, 2019