Fosmanogepix: A comprehensive review of its origin, mechanism, antifungal efficacy, and resistance (Review). (PubMed, Biomed Rep) - Oct 7, 2026 - "However, emerging resistance mechanisms, including Gwt1 target mutations (such as V162A/V163A), efflux pump overexpression mediated by transcription factor mutations (Tac1B, Tac1, Pdr1), and calcineurin-dependent calcium signaling activation, pose potential threats to its long-term clinical utility. The present narrative review summarized published findings on fosmanogepix, encompassing its origin, mechanism of action, antifungal efficacy, resistance mechanisms, and combination strategies through in vitro, in vivo, and clinical investigations."
Journal • Review • Candidiasis • Infectious Disease • Pulmonary Disease • Respiratory Diseases
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Guoxing Zhu; Nanyi Zheng; Pengfei Zhai; Yi Mou
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