In vitro study on synergistic antifungal effects of docetaxel combined with azoles against dematiaceous fungi and Aspergillus niger. (PubMed, Front Microbiol) - Aug 2, 2026 - "CLSI M38-A2 microbroth dilution method was used to detect fractional inhibitory concentration index of DTX with posaconazole (POS), itraconazole (ITC), voriconazole (VOR), and isavuconazole (ISA) against 43 fungi (including 24 strains of Exophiala dermatitidis, 7 strains of Exophiala alcalophila, 3 strains of Fonsecaea pedrosoi, 1 strain of Fonsecaea monophora, 1 strain of Exophiala verrucosa and 7 strains of Aspergillus niger). The combined scheme of DTX and POS can significantly reduce the minimum inhibitory concentration of POS and show synergistic antifungal activity, especially significant against E. dermatitidis and A. niger. Its mechanism of action may be related to the reduction of efflux pump activity."
Journal • Preclinical • Infectious Disease
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Heng Zhang; Hua Ni; Kai Tian; Lu Ge; Mengqi Peng; Tian Chen; Xueying Zhang; Yi Sun
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