Rhino-Orbital Mucormycosis Following COVID-19 Viral Vector Vaccination in an Immunocompetent Patient. (PubMed, J Fungi (Basel)) - Jul 28, 2026 - "We report a severe case in a previously healthy 44-year-old immunocompetent man who developed acute left-sided exophthalmos, ophthalmoplegia, severe visual loss, and systemic deterioration 10 days after AZD1222 COVID-19 vaccination. Clinical and radiologic findings suggested invasive rhino-orbital fungal disease, prompting immediate liposomal amphotericin B, broad-spectrum antibiotics, urgent endoscopic sinus surgery, and repeated orbital-sinonasal debridements with amphotericin B irrigation...Therapy was later adjusted to include isavuconazole and antibacterial coverage for persistent inflammation and secondary colonization...Although causality with vaccination cannot be established, the temporal association and biological plausibility warrant further investigation. Early suspicion and prompt combined medical-surgical management are essential in rapidly progressive orbital cellulitis."
Journal • Dermatology • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Novel Coronavirus Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Respiratory Diseases
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Adriana Iuliano; Antonella D'Aponte; Biagio Pinchera; Ciro Costagliola; Dana Cohen; Davide Tramontano; Diego Strianese; Francesco Matarazzo; Ivan Gentile; Maria Laura Passaro; Maria Paola Laezza; Mario Troisi; Vittoria Lanni
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