Development of a 3-Amino-1-carboxymethyl-β-lactam-Based Monocyclic Ceftobiprole Analog. (PubMed, Chem Asian J) - Jul 7, 2026 - "The target structure was synthesized via a modular approach, employing two Wittig reactions as key steps. Biochemical evaluation revealed that the ethyl ester derivative exhibited significant inhibition of S. pneumoniae PBP1b, highlighting this new framework as a valuable starting point for further optimization."
Journal • Infectious Disease • Pneumonia
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Katarina Magdalenic; Kato Bredael; Lena Decuyper; Martina Hrast Rambaher; Matthias D'hooghe; Stanislav Gobec
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