Transferrin Enhances Antifungal Therapy and Improves Survival in Experimental Mucormycosis. (PubMed, J Fungi (Basel)) - Sep 25, 2026 - "Checkerboard assays demonstrated synergistic interactions between transferrin and liposomal amphotericin B (LAMB), with fractional inhibitory concentration index values below 0.5 for all tested species. In a neutropenic murine model of pulmonary mucormycosis, transferrin enhanced the therapeutic efficacy of both LAMB and isavuconazole (ISAV), resulting in improved survival compared with antifungal monotherapy. Collectively, these findings provide preclinical evidence that transferrin modulates pathogenic determinants associated with mucormycosis and enhances the efficacy of current antifungal therapies, supporting further investigation of transferrin as a potential host-directed adjunctive treatment."
Journal • Infectious Disease • HSPA5
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Andrew Chan; Ashraf S Ibrahim; Belal A Ibrahim; Keenan Harb; Teclegiorgis Gebremariam; Yiyou Gu
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