Breakthrough Tracheobronchial Aspergillosis Caused by Aspergillus calidoustus and Aspergillus niger in a Lung Transplant Recipient Despite Combined Antifungal Prophylaxis. (PubMed, Case Rep Pulmonol) - Jun 23, 2026 - "We present the case of a 61-year-old male with a history of idiopathic pulmonary fibrosis who was admitted to our hospital for a unilateral lung transplant that was performed without complications; despite voriconazole prophylaxis, he developed tracheobronchial aspergillosis, caused by A. niger and A. calidoustus-a species difficult to identify due to its close microbiological and genetic resemblance to other Aspergillus species. Molecular diagnostic methodologies are indispensable for the precise identification of cryptic Aspergillus species, a necessity emphatically demonstrated by this specific clinical presentation. The reliance upon these tools, in contrast to conventional phenotyping, is crucial for guiding appropriate and potentially life-saving antifungal therapeutic interventions in critical scenarios like lung transplantation."
Journal • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Transplantation
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Adrian Camacho Ortiz; Carlos Enrique Calvache Benavides; Martha Daniela Rodríguez Cárdenas; Rogelio de Jesús Treviño Rangel; Sergio Saul Sánchez Salazar
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