Treatment of Acute Tacrolimus Toxicity with Phenytoin After Itraconazole Therapy in a Kidney Transplant Recipient (ATC 2026) - Jun 17, 2026 - Abstract #Abstract D327; Pres time: Jun 23, 2026; 02:30 PM - 03:30 PM; Location: Exhibit Hall; "Isavuconazole, a moderate CYP3A4 inhibitor, was started based on susceptibility testing and tacrolimus was cautiously restarted at a lower dose.* This case highlights the use of phenytoin, a potent CYP3A4 inducer, to manage acute tacrolimus toxicity in kidney transplant recipients. This case highlights the use of phenytoin, a potent CYP3A4 inducer, to manage acute tacrolimus toxicity in kidney transplant recipients. The route of administration of phenytoin has been shown to influence outcomes with the IV route associated with more rapid correction but with more side effects. Our case adds to the body of literature that oral phenytoin appears to be a safe and effective strategy to rapidly reverse tacrolimus toxicity."
Clinical • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Transplantation • Type 2 Diabetes Mellitus
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M. Pittappilly; B. Tamimi; M. Sharshir; D. Khirfan; B. Alper
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