Fatal Case of Severe Fever with Thrombocytopenia Syndrome Complicated by Profound Neutropenia and Invasive Trichosporonosis. (PubMed, J Infect Chemother) - Sep 25, 2026 - "A 71-year-old woman was clinically diagnosed with hemophagocytic lymphohistiocytosis, for which she received corticosteroids and etoposide. She was transferred to our hospital and diagnosed with SFTS, and favipiravir was immediately initiated. She developed profound neutropenia and subsequently progressed to respiratory failure necessitating mechanical ventilation, for which she was empirically treated with piperacillin/tazobactam and micafungin. Shortly thereafter, progressively elevated serum Aspergillus galactomannan antigen levels raised concern for invasive fungal infection, particularly invasive pulmonary aspergillosis, prompting a switch in antifungal therapy to isavuconazole...Despite antifungal treatment and intensive supportive care, the patient died of multiple organ failure. This case highlights the need for close hematologic monitoring and vigilance for invasive fungal infections, including uncommon pathogens such as Trichosporon species, in patients..."
Journal • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Neutropenia • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Thrombocytopenia
|
|
Ami Koizumi; Asami Yamada; Hirotomo Nakata; Jun-Ichirou Yasunaga; Kenichi Koga; Rie Furuta; Takanori Horiguchi; Takayuki Shinohara; Yoshitsugu Miyazaki
|