Isavuconazole Prophylaxis and Treatment in Pediatric HSCT Recipients: Pharmacokinetics, Safety, and Efficacy. (PubMed, Int J Antimicrob Agents) - Jun 8, 2026 - "Isavuconazole provides effective and safe IFD prophylaxis in pediatric HSCT recipients. A Cmin target of 1-3 mg/L is sufficient for prophylaxis, distinct from the higher therapeutic targets typically recommended for treatment. Routine TDM remains critical to optimize dosing and ensure target attainment, particularly in children <6 years."
Journal • PK/PD data • Bone Marrow Transplantation • Infectious Disease • Pediatrics • Transplantation
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Ding-Ming Liu; Hao Jiang; Jie Zheng; Jun Yang; Lixiao Cai; Mao-Quan Qin; Ningning Chen; Pan Zhang; Ximu Sun; Yuanfang Jing
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