Prospective study of pharmacokinetics of isavuconazole in critically ill patients undergoing continuous hemodialysis with and without acute-on-chronic liver failure. (PubMed, Ann Intensive Care) - May 30, 2026 - "ACLF did not significantly alter isavuconazole clearance during RRT. However, high PK variability and frequent subtherapeutic exposures support routine therapeutic drug monitoring in critically ill patients."
Journal • PK/PD data • Critical care • Hepatology • Infectious Disease • Liver Failure
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Christina König; Dominik Jarczak; Emily Behrens; Jens Martens-Lobenhoffer; Jörn Grensemann; Sebastian G Wicha; Stefan Kluge; Stefanie M Bode-Böger; Valentin Fuhrmann
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