Invasive sino-orbital aspergillosis with intracranial extension: a multidisciplinary and ethical dilemma in pursuing aggressive surgery versus palliation. (PubMed, BMJ Case Rep) - May 29, 2026 - "Biopsy confirmed invasive fungal sinusitis with septate hyphae and culture identified Aspergillus fumigatus.Initial treatment with amphotericin B was complicated by acute kidney injury, prompting a switch to posaconazole. Due to disease progression, therapy was escalated to isavuconazole, alongside right orbital exenteration and skull-base debridement.At 12 months, she was symptom-free and remains on lifelong isavuconazole; MRI at 16 months showed no recurrence.This case highlights diagnostic challenges, targeted antifungal therapy and multidisciplinary surgical management in advanced sino-orbital aspergillosis, alongside the ethical complexity of choosing radical surgery over palliation with intracranial extension."
Journal • Acute Kidney Injury • Breast Cancer • CNS Disorders • Diabetes • Infectious Disease • Metabolic Disorders • Multiple Sclerosis • Nephrology • Oncology • Otorhinolaryngology • Pain • Pulmonary Disease • Renal Disease • Respiratory Diseases • Sinusitis • Solid Tumor • Type 2 Diabetes Mellitus
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Ali Qureishi; Haleema Siddique; Sanjeeva Jeyaretna; Zahir Mughal
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