Can voriconazole gradient diffusion testing results be extrapolated to isavuconazole and posaconazole in Aspergillus spp.? Comparative analysis with CLSI broth microdilution and cyp51A gene sequencing.

Cresemba (isavuconazonium sulfate) - Astellas, Basilea

voriconazole - Generic mfg.

Noxafil (posaconazole) - Merck (MSD)

Can voriconazole gradient diffusion testing results be extrapolated to isavuconazole and posaconazole in Aspergillus spp.? Comparative analysis with CLSI broth microdilution and cyp51A gene sequencing. (PubMed, Antimicrob Agents Chemother) - May 18, 2026 - "VRC-PSC extrapolation was reliable in both species, whereas VRC-ISA extrapolation was species-dependent. Gradient diffusion underestimated resistance detection in some cyp51A-mutant isolates, highlighting the risk of false-susceptible interpretations."
Journal

http://www.ncbi.nlm.nih.gov/pubmed/42138696

; Anna-Sophia Nickel; Cornelia Lass-Flörl; David Eisele; Roya Vahedi-Shahandashti

May 18, 2026