Disseminated Fusariosis, Leukemia Cutis, and Acute Sinus Disease in Prolonged Neutropenia from Acute Myeloid Leukemia (CIS 2026) - May 13, 2026 - "Prior therapies included avapritinib, decitabine/venetoclax, and enrollment in a vyxeos-gliteritinib clinical trial; he remained profoundly neutropenic (absolute neutrophil count [ANC] <20)...He was managed with liposomal amphotericin B, voriconazole, and terbinafine, along with meropenem and vancomycin. Due to Fusarium's high azole and amphotericin minimum inhibitory concentrations (MICs) at our institution, fosmanogepix was requested but anticipated to arrive in two weeks...Early recognition of the clinical triad of respiratory involvement, severe myalgia, and skin lesions may suggest Fusarium etiology in severely neutropenic patients. Successful management requires prompt diagnosis, appropriate combination antifungal therapy, and most critically, neutrophil recovery, which represents the single most important prognostic factor."
Acute Kidney Injury • Acute Myelogenous Leukemia • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Hepatology • Immunology • Infectious Disease • Leukemia • Musculoskeletal Pain • Myelodysplastic Syndrome • Nephrology • Neutropenia • Otorhinolaryngology • Pneumonia • Renal Disease • Respiratory Diseases • CSF2
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Katarzyna Karpinska-Leydier; Justin Doherty; John Greene
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