Candida (Candidozyma) auris strains exposed to azole fungicides become less susceptible to manogepix. (PubMed, Med Mycol) - May 1, 2026 - "Exposure resulted in a rapid and significant increase in fungicide MICs, accompanied by a reduced susceptibility to four azole antifungals (fluconazole, voriconazole, posaconazole, isavuconazole), and to a new antifungal agent, the manogepix. One of these strains showed a significant overexpression of the efflux pump CDR1. These findings provide experimental evidence that azole fungicides can drive resistance to azole antifungals and reduce susceptibility to manogepix, underscoring the need for integrated One Health antifungal stewardship strategies to combat C. auris."
Journal • Infectious Disease
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Adrien Baillod; Audrey Boutillier; Jeremy Moreau; Jérôme Labanowski; Jonathan Clarhaut; Kévin Brunet; Sandrine Marchand
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