Risk stratification of ibrutinib toxicity co-administered with triazole antifungals: insights from real-world pharmacovigilance and clinical evidence. (PubMed, Front Med (Lausanne)) - Sep 16, 2026 - "Voriconazole-containing reports showed a signal for cerebral aspergillosis (ROR = 474.61, n = 3), posaconazole-containing reports showed cardiac events including pericardial effusion (ROR = 24.95, n = 4), and isavuconazole-containing reports showed a signal for febrile neutropenia (ROR = 29.7, n = 4). The identified pharmacovigilance signals are clinically interpretable in light of known CYP3A-mediated pharmacokinetic interactions, but they should be considered hypothesis-generating rather than causal. These findings support clinical awareness, individualized medication review, and further validation in studies with defined denominators and appropriate control of confounding."
Adverse events • Journal • Real-world evidence • Cardiovascular • Febrile Neutropenia • Hematological Disorders • Neutropenia • Pulmonary Disease • Respiratory Diseases
|
|
Shiqiao Wang; Shiyun Li; Zijuan Li
|