A novel GWT1 A397T substitution combined with TAC1B F214I reduces manogepix susceptibility and fosmanogepix efficacy in Candida auris. (PubMed, Microbiol Spectr) - Sep 2, 2026 - "The combined changes were also associated with a reduced response to fosmanogepix in an insect infection model. These findings show that changes affecting the drug target and drug efflux may act together to reduce antifungal activity and support monitoring for multiple pathways of reduced susceptibility."
Journal • Infectious Disease
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Hiroshi Mukae; Katsunori Yanagihara; Kazuhiro Tsukamoto; Koichi Izumikawa; Koichi Makimura; Mizuki Ishimine; Nana Nakada; Naoki Iwanaga; Natsume Kitahori; Taiga Miyazaki; Takahiro Takazono; Tatsuro Hirayama; Yuya Ito
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