Targeted blood-brain barrier penetration for traumatic brain injury therapy via RXR/PPAR-driven microglial M2 polarization. (PubMed, Mater Today Bio) - Aug 29, 2026 - "We designed a biomimetic nanomedicine (Ali-NPs@Mexo) by encapsulating alitretinoin(Ali)-loaded albumin nanospheres within mesenchymal stromal cell (MSC)-derived exosomal membranes...In vivo, Ali-NPs@Mexo significantly improved functional and cognitive outcomes in mice. This integrated strategy of targeted immune-modulation and neuro-regeneration provides a translatable framework for effective TBI intervention."
Journal • CNS Disorders • Immune Modulation • Immunology • Inflammation • Solid Tumor • Vascular Neurology
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Dongming Gao; Junyu Lin; Lei Li; Liang Gao; Lin Zhou; Songyu Chen; Xiao Hou; Xiaxuan Zhang; Zhicheng Xu
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