Tintelnotia destructans Invasive Rhinosinusitis in an Immunocompromised Child: A Case Report and Review of the Literature. (PubMed, Open Forum Infect Dis) - Oct 1, 2026 - "Combined endoscopic surgical debridement, antifungal therapy (liposomal amphotericin B and isavuconazole), and immune reconstitution after emergency haploidentical hematopoietic stem cell transplant ultimately led to complete recovery without recurrence 18 months after treatment, despite continued therapeutic immunosuppression for graft-vs-host disease. This case expands the known pathogenic spectrum of T. destructans, demonstrating its potential to cause invasive disease in severely immunocompromised hosts. Advances in molecular diagnostic tools may expand the spectrum of fungi causing invasive fungal infections by identification of novel pathogenic species."
Journal • Aplastic Anemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Respiratory Diseases • Sinusitis • Transplantation
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Antoine Reinhard; Claire Bertelli; Estelle Dubruc; Frederic Lamoth; Frida Rizzati; Jizhou Li; Manon Jaboyedoff; Pierre Alex Crisinel; Raffaele Renella
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