Pharmacokinetic and pharmacokinetic/pharmacodynamic (PK/PD) considerations of ceftaroline and ceftobiprole for the treatment of Staphylococcus aureus infections: a systematic review. (PubMed, Int J Antimicrob Agents) - Aug 11, 2026 - "Ceftaroline and ceftobiprole pharmacokinetics are highly variable in hospitalized patients, potentially compromising attainment of stringent pharmacokinetic/pharmacodynamic targets for S. aureus infections. Intensified doses and prolonged infusions may therefore be necessary to ensure adequate drug exposure."
Journal • PK/PD data • Review • Infectious Disease
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Alex Soriano; Andrea Gori; Camilla Genovese; Donatella Maddalena; Enrico Sguazzini; Fekade B Sime; Jason A Roberts; Marta Colaneri; Marta Ulldemolins; Mohd-Hafiz Abdul-Aziz
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