Pharmacokinetics of Isavuconazole in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation (ECMO) Support: A Prospective Exploratory Observational Study. (PubMed, Pharmaceutics) - Sep 27, 2026 - "All patients achieved predefined PK/PD efficacy targets using currently recommended dosing regimens; however, interindividual PK variability was observed, supporting the potential value of therapeutic drug monitoring (TDM) to guide individualized dosing decisions in this population. Larger population PK studies are warranted to further characterize determinants of isavuconazole exposure during ECMO support and refine evidence-based dosing strategies."
Journal • Observational data • PK/PD data • Critical care
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Adrián Tellez Santoyo; Alba Escolà-Rodríguez; Albert Carramiñana; Carla Bastida; Carlos Roca; Cristina Espinosa; Dolors Soy Muner; Elena Sandoval; Jaime I Sainz de Medrano; Jorge Moisés; Marta Hernández Meneses; Mercè Brunet Serra; Pedro Castro; Sabina Herrera
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