Physiologically based pharmacokinetic (PBPK) model to predict the magnitude of drug-drug interaction between vincristine and the azole antifungals isavuconazole, posaconazole, and voriconazole in children.

Cresemba (isavuconazonium sulfate) - Astellas, Basilea

vincristine - Generic mfg.

voriconazole - Generic mfg.

Noxafil (posaconazole) - Merck (MSD)

http://www.ncbi.nlm.nih.gov/pubmed/42484904

Amit Desai; Laura Lynn Kovanda; Mary P Choules; Peter L Bonate; Roger J Brüggemann; Yukio Otsuka

Jul 23, 2026