Variability in belumosudil exposure due to coadministration of voriconazole and isavuconazole in a patient with chronic graft-versus-host disease: Case report. (PubMed, Int J Clin Pharmacol Ther) - Aug 6, 2026 - "Belumosudil exposure varied according to the degree of CYP3A4 inhibition (voriconazole > isavuconazole). These intra-patient data, together with clinical factors affecting absorption and hepatic function, support consideration of TDM and careful antifungal selection when combining belumosudil with azoles, particularly in pulmonary cGVHD where treatment responses are often limited."
Journal • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Transplantation
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Mari Shimoda; Masao Tsukada; Saori Aizawa; Takeo Yasu; Yoshito Gando
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