Mutations in MRR1 that confer fluconazole resistance in C. parapsilosis and C. albicans confer cross-resistance to manogepix. (PubMed, Clin Microbiol Infect) - Aug 5, 2026 - "Our findings demonstrate that fluconazole and manogepix cross-resistance in C. parapsilosis conferred by MRR1-activating mutations is mediated by Cdr1b and Mdr1b transporters. MRR1-activating mutations conferred cross-resistance, to a lesser degree, in C. albicans, but independent of drug transporters known to be regulated by Mrr1."
Journal • Candidiasis • ABCB1
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Hoja P Patterson; Joachim Morschhäuser; Katherine S Barker; Nathan P Wiederhold; P David Rogers
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