A programmable nanoplatform for inflammatory-state reprogramming in psoriasis treatment. (PubMed, J Nanobiotechnology) - Oct 22, 2026 - "In an imiquimod-induced mouse model of psoriasis (both ear and back), TA-Ce-Lut-Gel significantly reduced skin inflammation, improved skin thickness, erythema, and scaling, showing superior efficacy compared to traditional anti-inflammatory treatments...Additionally, combined with NIR irradiation, TA-Ce-Lut-Gel enhanced transdermal drug delivery and antioxidant activity, further enhancing therapeutic effects and promoting skin microbiota recovery. This study presents an effective platform for localized precise treatment of psoriasis, overcoming the limitations of traditional single-target anti-inflammatory therapies and offering a potential strategy for the treatment of other immune-mediated diseases, with broad clinical application prospects."
Journal • Dermatitis • Dermatology • Immune Modulation • Immunology • Inflammation • Psoriasis • TRAF6
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Ge Lou; Jingchun Jin; Jinyu Zhao; Mingji Jin; Shiqi Huang; Shuangqing Wang; Zheng Nan; Zhihua Chen; Zhonggao Gao
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