Potential role of druggable gene SLC15A2 in keratinocyte hyperproliferation in psoriasis. (PubMed, Gene) - Oct 20, 2026 - "These findings were then validated using an imiquimod-induced psoriasis-like mouse model, single-cell transcriptomics, and in vitro functional assays...Drug screening and molecular docking further indicated that SLC15A2 could be modulated by small molecules. Overall, these results suggest that SLC15A2 is a potential pathogenic gene with therapeutic relevance in psoriasis, providing insights into its role in keratinocyte hyperproliferation."
Journal • Dermatology • Immunology • Inflammation • Psoriasis
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Chushan Huang; Pengsheng Chen; Xiaosong Chen
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