RAC1-YAP1-PIEZO1 signaling axis links intrauterine inflammation to uterine hypercontractility and preterm labor. (PubMed, Biol Reprod) - Oct 18, 2026 - "Pharmacological inhibitors (Verteporfin for YAP1 and NSC23766 for RAC1) and Rac1 siRNA were utilized to investigate the functional roles and regulatory relationships among these molecules. Our findings suggest that RAC1 is involved in regulating YAP1 activation and nuclear localization, which is associated with increased PIEZO1 expression and uterine smooth muscle contractility. Thus, targeting the RAC1-YAP1-PIEZO1 axis might represent a novel strategy for preventing infection-induced preterm birth."
Journal • Infectious Disease • Inflammation • RAC1 • YAP1
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Hao Li; Lu Huang; Min Diao; Qian Liu; Xuemei Lin; Yanmei Bi; Yantong Wan; Yi Qu; Yunkai Tao
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