From Active Compound to Target Epithelium: Local Delivery, Preclinical Model Validity, and Clinical Endpoint Interpretation in Topical Therapy for HPV-Associated Lower Genital Tract Disease-A Narrative Review. (PubMed, J Clin Med) - Oct 17, 2026 - "Randomized evidence supports imiquimod as a non-surgical option for appropriately selected women with vulvar high-grade squamous intraepithelial lesions; cervical conclusions depend on comparator and endpoint. We propose a conceptual eight-element sequence from clinical intention to inference, an interpretive aid, and not a validated appraisal instrument. Future studies should prespecify these elements and characterize exposure where feasible."
Journal • Preclinical • Review • Cervical Cancer • Gynecology • Oncology
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Claudia Florida Costea; Iustina Petra Solomon Condriuc; Raluca Haba; Sandra Teodora Gavril; Vasile Adrian Sescu
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