The NMDAR positive allosteric modulator NYX-783 selectively blocks opioid withdrawal conditioned place aversion in mice.

naltrexone - Generic mfg.

methadone - Generic mfg.

NYX-783 - Aptinyx

http://www.ncbi.nlm.nih.gov/pubmed/41040268

Deven M Diaz; Ethan Foscue; Jane R Taylor; Joseph R Trinko; Rajita Sinha; Ralph J DiLeone; Robert T Malison; Summer L Thompson

Oct 3, 2025