CD8 T-cell exhaustion linked with CAR T-cell failure can be mitigated by a non-alpha IL2 receptor agonist. (PubMed, Blood) - Oct 25, 2026 - "In vivo CART19 alone led to transient response followed by progression and secondary central nervous system relapse in this model, while the addition of pegenzileukin to CART19 led to the complete eradication of tumors. This provides mechanism-informed pre-clinical rationale for the use of non-alpha IL2 receptor agonists in combating T-cell exhaustion, a critical mechanism of CART19 failure."
Journal • B Cell Lymphoma • Hematological Malignancies • Large B Cell Lymphoma • Lymphoma • Non-Hodgkin's Lymphoma • Oncology • IL2
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Ashley Lauren Wilson; Christan Dillard; Dinesh S Bangari; Donald Shaffer; Enyu Dai; Estela Rojas; Francisco Vega; Fuliang Chu; Haopeng Yang; Irtiza N Sheikh; Jared Henderson; Jason R Westin; Katie Malley; Kevin Bowman; Kotaro Arita; Linghua Wang; Michael R Green; Nathan Michael Pate; Patrick K Reville; Robert Andrew Harkins; Rui Wang; Sairah Ahmed; Sattva S Neelapu; Xiangming Li; Xubin Li
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