DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling.

CAR-T cells - Chinese PLA General Hospital

http://www.ncbi.nlm.nih.gov/pubmed/41844571

Chuan Tong; Fuxin Han; Jianshu Wei; Jinhong Shi; Liang Dong; Qi Zhu; Weidong Han; Xinran Ma; Yang Zhang; Yao Wang; Yelei Guo; Yuting Lu; Zhenzhen Meng; Zhi Cao; Zhiqiang Wu

Mar 18, 2026