Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1. (PubMed, Cell Chem Biol) - Apr 17, 2026 - "Here, cryo-EM structures of the HHV1 (α-subfamily) HPC bound to single-stranded DNA and two clinical inhibitors, amenamevir and pritelivir, are reported. Combined molecular dynamics and fragment molecular orbital analyses explain the α-subfamily selectivity and distinct antiviral spectra of these drugs. These findings provide a structural framework to guide the development of novel inhibitors targeting β- and γ-subfamily herpesviruses."
Journal • CNS Disorders • Epstein-Barr Virus Infections • Immunology
|
|
Asako Oguni; Chikako Okada; Hidetoshi Kono; Hisashi Ishida; Kaori Fukuzawa; Keisuke Hamada; Ko Sato; Osamu Nureki; Shunsuke Kobayashi; Toma Miyagishi; Toru Sengoku; Yoshiaki Kise
|