ΑΒT/CD19 DEPLETED HAPLOIDENTICAL STEM CELL TRANSPLANTATION IS A SAFE AND EFFECTIVE SALVAGE THERAPY IN HEAVILY PRETREATED RELAPSED/REFRACTORY PATIENTS WITH HODGKIN LYMPHOMA (EBMT 2026) - Mar 14, 2026 - Abstract #A262; Pres time: Mar 23, 2026; 06:00 PM - 07:00 PM; Location: VELAZQUEZ; "Conditioning consisted of ATG 1,5 mg/kg from day -13 to day -10, Treosulfan 12gr/sqm from -9 to –7, Fludarabine 30mg/sqm from -6 to -2 and Thiotepa 5mg/Kg on days -5 and -4...One patient died because of recurrent CMV reactivation in patient with an unfavorable sierology R POS/D NEG in pre letermovir era and the other one due to GVHD post Donor lymphocyte Infusion...CMV reactivation occurred, in 5 patients, with one experiencing organ disease, and EBV reactivation in three, that completely responded to 2 cycles of Rituximab... Allogenic transplantation with ab T cell depletion is an effective and safe approach in relapsed/refractory Hodgkin lymphoma heavily pretreated, with a rapid donor hematopoietic engraftment and very promising outcome, with a very low transplant related mortality in patients heavily pretreated before HSCT."
Clinical • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Hematological Malignancies • Hodgkin Lymphoma • Immunology • Infectious Disease • Lymphoma • Transplantation • CD34 • NCAM1
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Amelia Rinaldi1; Sabrina Bonomini1; Roberta Segreto1; Benedetta Cambò1; Maria Teresa Giaimo1; Gabriella Sammarelli1; Caterina Plenteda1; Giannalisa Todaro1; Ramona Linciano1; Giovanni Roti1; Lucia Prezioso1
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