LATE CYTOMEGALOVIRUS REACTIVATION AFTER ALLOGENEIC HSCT PERSISTS IN THE ERA OF LETERMOVIR PROPHYLAXIS – A SINGLE-CENTRE REAL WORLD STUDY (EBMT 2026) - Mar 14, 2026 - Abstract #B141; Pres time: Mar 24, 2026; 06:00 PM - 07:00 PM; Location: VELAZQUEZ; "413/480 (86%) received reduced intensity conditioning regimens, and 397/480 were T-cell deplete (Campath 226/480; 47.1%, ATG 93/480; 19.4%, PTCy 79/480; 16.5%)...20/27 (74.1%) of the post-letermovir reactivators required treatment with an additional anti-viral agent (p=0.52); 3 required admission for treatment with foscarnet (2 having been pre-treated with valganciclovir)... CMV reactivation remains a frequent issue post-allo-HSCT. Letermovir defers the median onset of csCMV to post-D100, but does not reduce the need for further anti-viral treatment."
Clinical • Real-world • Real-world evidence • Bone Marrow Transplantation • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Graft versus Host Disease • Hematological Malignancies • Immunology • Lymphoma • Non-Hodgkin's Lymphoma • Ocular Inflammation • Ophthalmology • Pneumonia • Retinal Disorders
|
|
Louis Peters1,2; Charlotte Brierley1,2; Sheila Lumley1,2; Louise Downs1,2; Reegan Robertson2; Wen Yuen Lim1; Roberty Danby1,3; Katie Jeffery1,2; Kirsty Sharplin1,4
|