INTEGRATIVE BIOINFORMATIC AND REAL-WORLD DATA ANALYSIS REVEAL MECHANISTIC ASSOCIATIONS BETWEEN LETERMOVIR PROPHYLAXIS AND EBV REACTIVATION AFTER ALLOGENIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (EBMT 2026) - Mar 14, 2026 - Abstract #B085; Pres time: Mar 24, 2026; 06:00 PM - 07:00 PM; Location: VELAZQUEZ; "The use of letermovir for prophylaxis may contribute to a higher risk of EBV reactivation post allo-HSCT by disrupting key biological pathways involved in hypoxia, inflammation, and endothelial function. Our integrative model facilitates early identification of patients at high risk of EBV reactivation, guiding monitoring and intervention strategies."
Clinical • Real-world • Real-world evidence • Bone Marrow Transplantation • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Infectious Disease • Inflammation • Transplantation • CXCL8 • EGFR • HER-2 • HIF1A • PACERR • PPARG • PTGS2 • STAT3
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Zhangjie Chen1; Sisi Zhen1; Xin Chen1; Sizhou Feng1
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