LETERMOVIR PROPHYLAXIS RESHAPES EARLY IMMUNE RECONSTITUTION AND CMV/EBV REACTIVATION DYNAMICS AFTER ALLOGENEIC HSCT (EBMT 2026) - Mar 14, 2026 - Abstract #B190; Pres time: Mar 24, 2026; 06:00 PM - 07:00 PM; Location: VELAZQUEZ; "HSCT recipients receiving LTV prophylaxis exhibited a unique pattern of immune reconstitution characterized by early suppression of T cell numbers. However, by avoiding CMV-driven abnormal immune activation and exhaustion, they retained T cell TCR diversity, indirectly preserving robust T cell reserve capacity. This configuration is more conducive to the recovery of immune reconstitution in later stages."
Bone Marrow Transplantation • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Infectious Disease • CD4 • CD8
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Wei Zhao1; Man Chen1; Jing Long2; Yanli Zhao3; Peihua Lu3,2,1
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