Dynamic Mixed Populations of Resistant CMV in a Lung Transplant Recipient (ISHLT 2026) - Feb 2, 2026 - Abstract #Pub #769; Pres time: Apr 22, 2026; 06:00 PM - 07:00 PM; Location: Poster Hall; Board #349; "Despite these changes he required IV ganciclovir for rising viral loads, and after initial testing showed resistance only to cidofovir, the patient was transitioned back to valganciclovir...The patient once again developed viremia, and testing now showed resistance to maribavir, ganciclovir, and cidofovir for which foscarnet was restarted...Viral loads improved, and the patient was eventually transitioned to a letermovir/valganciclovir combination therapy, followed by maribavir/letermovir therapy after testing showed his maribavir resistance had resolved. Subsequent surveillance has shown CMV viral levels managed on dual therapy.Summary Prior literature has shown that antiviral therapy can select for resistant strains if mixed populations are present, leading to changes in genotypic susceptibility testing results over time. We present a case of highly resistance mixed genotype CMV populations with changing resistance profiles, that was successfully treated with..."
Clinical • Fibrosis • Immunology • Inflammation • Pneumonia • Pulmonary Disease • Transplantation
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P. Babinski 1; J. Gonzales 1; C. Myers 1; A. Kamar 1; K. Warrior 1; A. Betensley 1; A. Joudi 1; B. Bemiss 1; C. Kurihara 2; A. Bharat 2; A. Arunachalam 1; K. Kling 1; M. Venkata Subramani 1
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