Nicotinamide-based Sirtuin 2 inhibitors as anti-HCMV agents. (PubMed, Antiviral Res) - Jan 26, 2026 - "The combination of these SIRT2 inhibitors with standard antivirals such as ganciclovir or letermovir resulted in a generally additive profile. GAPDH expression was stable over time and did not increase in HCMV infected cells, indicating a possible sirtuin-specific mechanism for upregulation of SIRT2 and 1 expression in infected cells. Further investigation is required to better understand the underlying anti-HCMV mechanism of action for our SIRT2 inhibitors and how HCMV infection impacts SIRT2 expression."
Journal • Cytomegalovirus Infection • Infectious Disease • GAPDH • SIRT1 • SIRT2
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Daniel J Wilson; Dariya Begum; Liqiang Chen; Robert J Geraghty; Teng Ai
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