Letermovir shows antiviral and neuroprotective effects in differentiating neurons and cerebral organoids mimicking human developing brain. (PubMed, Cell Mol Life Sci) - Jan 11, 2026 - "This study contributes to shed light on HCMV-induced neuropathogenesis that occurs during congenital infection. Importantly, we demonstrated the neuroprotective effects of letermovir in models of human developing brain, holding promise for its evaluation as a candidate therapeutic agent to ameliorate cCMV-associated neurodevelopmental defects."
Journal • Cytomegalovirus Infection • Infectious Disease • Inflammation
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Anna Pianezzola; Arianna Loregian; Beatrice Mercorelli; Elisa Poli; Elisabetta Faggin; Giorgio Palù; Marta Trevisan; Ravit Arav-Boger
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