Reversion of Val(Ganciclovir)-Resistance-Associated Mutations in Two SOT Patients with Mismatched Serostatus for CMV (D+/R-). (PubMed, Viruses) - Nov 27, 2025 - "Following CMV DNA suppression, secondary prophylaxis with letermovir and val(ganciclovir) was initiated...Therapy was then switched to foscarnet, which was suspended due to renal failure, and then to maribavir...Detecting gene mutations that confer drug resistance is crucial for managing antiviral therapy when virological response is lacking. In our cases, the reversion of (va)ganciclovir-resistance mutations occurred after drug withdrawal, a previously unreported finding."
Journal • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Immunology • Renal Disease • Solid Organ Transplantation • Transplantation
|
|
Alessandra Tebaldi; Aurelia Sangani; Daniele Lilleri; Elena Seminari; Elizabeth Iskandar; Fausto Baldanti; Giulia Campanini; Paola Giordani; Raffaele Bruno; Stefania Paolucci
|