Key domains involved in the interaction and assembly of the HCMV terminase complex. (PubMed, Sci Rep) - Nov 21, 2025 - "Letermovir targets the viral terminase complex (pUL56, pUL89, pUL51), essential for DNA packaging, but resistance mutations in pUL56 underline the need for new antiviral strategies...Functional assays showed that 514EVNVRKRAY522 directly mediates interaction with pUL89, while modeling indicated that 671WMVVKYMGFF680 and 757YLLLYRHL764 stabilize the multimeric ring-shaped complex through contacts with pUL89 and pUL51. Our results suggest that two novel pUL56 regions are essential for terminase assembly and conformation and may represent promising targets for future antiviral development."
Journal • Cytomegalovirus Infection • Infectious Disease
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A Couvreux; C Gourin; C Lefevre; G Ligat; S Alain; S Hantz; T Flores
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