Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir. (PubMed, Sci Adv) - Nov 7, 2025 - "The structures reveal a bilobed architecture highlighting HP coordinated action at the replication fork and providing a structural basis for HP inhibition by illustrating precisely how pritelivir and amenamevir block helicase activity. Data lay a solid foundation for the development of improved antiviral therapies."
Journal • Herpes Simplex • Infectious Disease • RPL11
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Andrey G Baranovskiy; Ci Ji Lim; Lucia M Morstadt; Nigar D Babayeva; Qixiang He; Tahir H Tahirov; Yoshiaki Suwa
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