Refractory CMV Enteritis in Small Bowel Transplantation: A Case Highlighting the Challenges of Balancing Immunosuppression and Novel Antiviral Therapies. (PubMed, Viruses) - Oct 29, 2025 - "He developed refractory CMV disease, marked by non-response to first line therapy with ganciclovir-despite the absence of genotypic resistance-necessitating sequential use of foscarnet, dual antivirals, CMV immunoglobulin, and novel agents (maribavir and letermovir). Profound immunosuppression required to manage acute graft rejection episodes complicates antiviral management and disease clearance. Despite best efforts in CMV management in this population, outcomes may still be compromised by unrelated or compounding factors."
Journal • Cytomegalovirus Infection • Gastrointestinal Disorder • Transplant Rejection • Transplantation
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Abdulrahman A Al-Saud; Amani H Yamani; Ehab H Abufarhaneh; Fatimah S Alhamlan; Madain S Alsanea; Reem M Alameer; Reem S Almaghrabi
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