Integrated Life Cycle Assessment Guides Sustainability in Synthesis: Antiviral Letermovir as a Case Study. (PubMed, J Am Chem Soc) - Oct 27, 2025 - "Identification of bottlenecks in both syntheses revealed negative impacts on the sustainability in asymmetric catalysis as well as metal-mediated couplings, highlighting the continued demand for sustainable catalytic approaches that minimize adverse effects on global warming potential, ecosystem quality, human health, and natural resources. This comprehensive strategy for multilevel sustainability assessment increases the accuracy, facilitates comparisons, and enables targeted optimization of sustainability in organic chemistry."
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Erick M Carreira; Gonzalo Guillén-Gosálbez; Javier Pérez-Ramírez; Maximilian G Hoepfner; Sander Folkerts
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