Deciphering Letermovir's Mode of Action and Resistance Mutation Effects. (PubMed, Antiviral Res) - Oct 10, 2025 - "These findings suggest letermovir does not act by directly inhibiting interactions among HCMV terminase subunits. Analysis of resistance-associated mutations provides insight into the molecular basis of HCMV resistance to letermovir and may inform development of novel antiviral strategies targeting the terminase complex."
Journal • Cytomegalovirus Infection • Infectious Disease • Oncology
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C Gourin; C Lefevre; G Ligat; S Alain; S Hantz; T Flores
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