Functional and structural insights into HCMV terminase accessory proteins pUL77 and pUL93. (PubMed, J Virol) - Sep 16, 2025 - "Letermovir (LTV), which targets the viral terminase complex (pUL56-pUL89-pUL51), has improved prophylaxis in transplant recipients, but resistance mutations have already emerged...Here, we focused on two proteins, pUL77 and pUL93, which are associated with the viral capsid and interact with the terminase complex. By analyzing their polymorphism, structure, and functional motifs, we identified essential nuclear localization motifs and conserved regions in these proteins, providing valuable insights for the development of innovative anti-HCMV strategies, such as inhibitory peptides, which could complement existing treatments and address the ongoing challenge of antiviral resistance."
Journal • Cytomegalovirus Infection • Infectious Disease • Transplantation
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C Delmon; C Gourin; F Di Meo; S Alain; S Hantz
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