Added-value of high-throughput sequencing for early detection of HSV-2 resistant subpopulations in the helicase-primase inhibitors era: A case report. (PubMed, Int J Antimicrob Agents) - Sep 13, 2025 - "Immunocompromised patients are at high risk of developing acyclovir-resistant (ACV) herpes simplex virus (HSV) infections. Helicase-primase inhibitors, including pritelivir (PTV), represent an antiviral option to nephrotoxic alternatives...HTS technologies enhance sensitivity over conventional methods and provide valuable insights for managing antiviral resistance. Continuous monitoring and research to elucidate the functional impact of specific mutations of unknown significance on drug resistance are essential for building robust HSV resistance databases."
Journal • Herpes Simplex • Infectious Disease
|
|
A Renzoni; C Espinasse; D Neofytos; E Calfapietra; E Frobert; F Laubscher; F Morfin; L Royston; M Schibler
|