Population pharmacokinetic analysis of letermovir in adult hematopoietic cell transplant recipients. (PubMed, Antimicrob Agents Chemother) - Aug 22, 2025 - "Covariates associated with increased oral clearance (CL/F), possibly contributing to this observation, included: higher weight, younger age, and early use after HCT. The clinical significance and mechanistic explanation of relatively lower real-world exposure remains to be elucidated."
Journal • PK/PD data • Bone Marrow Transplantation • Cytomegalovirus Infection • Transplantation
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Carla Kunz; David Tonoli; Dionysios Neofytos; Léna Royston; Pierre Lescuyer; Verena Gotta
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