A comparative performance evaluation of the VIDAS cytomegalovirus (CMV) interferon-gamma release assay (IGRA) and T-SPOT CMV for measuring CMV-specific T-cell responses in allogeneic hematopoietic stem cell transplant recipients receiving letermovir prophylaxis. (PubMed, J Clin Microbiol) - Jul 28, 2026 - "In this clinical setting, tailoring the duration of LMV prophylaxis based on CMV-CMI at the time of drug discontinuation has emerged as a promising application of these assays. Our data revealed substantial qualitative and quantitative differences between the assays, which should be taken into consideration in future observational studies or clinical trials assessing the utility of IGRAs for individualizing LMV prophylaxis duration."
Journal • Bone Marrow Transplantation • Cytomegalovirus Infection • Infectious Disease • Transplantation
|
|
Ariadna Pérez; Carlos Martin; Carlos Solano; Carlos Solano de la Asunción; David Navarro; Eliseo Albert; Estela Gimenez; Ester Colomer; Irene García Cadenas; Jose Luis Piñana; Lourdes Vázquez; María Jesús Pascual; Olga Aso; Pablo Granados; Soukaina Boutriq
|